Would be interesting to use vvvv between webcam and software with video input (e.g. flash or skype) to add some image processing on the client-side and then send to the net.
In other words - system driver, to see vvvv as one of the video input devices.
aren’t there screen-recording tools that let you stream to skype? then you could select vvvv renderer to be streamed to it.
could be slow though. and performance will always be a problem in such a scenario, as vvvvs output is on the GPU (graphiccard) and will always need to be pulled back to system-mem in order to be used within another sofware. this is typically a slow process (depending on your image size and framerate requirements).